Name | Alosetron hydrochloride |
Synonyms | GR 68755 GR 68755C GR 68755X ALOSETRON HCL ALOSETRON HYDROCHLORIDE Alosetron hydrochloride 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one hydrochloride 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1h-imidazol-4-yl)methyl]-1h-pyrido[4,3-b]indol-1-one hydrochloride 2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one Hydrochloride |
CAS | 122852-69-1 |
EINECS | 802-450-0 |
InChI | InChI=1/C17H18N4O.ClH/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;/h3-6,10H,7-9H2,1-2H3,(H,18,19);1H |
Molecular Formula | C17H19ClN4O |
Molar Mass | 330.81 |
Melting Point | 288-291°C |
Boling Point | 648.1°C at 760 mmHg |
Flash Point | 345.8°C |
Solubility | H2O: ≥5mg/mL at warmed |
Vapor Presure | 1.1E-16mmHg at 25°C |
Appearance | powder |
Color | white to beige |
Storage Condition | 2-8°C |
MDL | MFCD09028027 |
Use | It is a highly selective 5-HT3 receptor antagonist used in the treatment of irritable bowel syndrome. Alosetron hydrochloride is a 5-HT receptor antagonist, which can inhibit the activity of non-selective cation channels, thereby regulating the enteric nervous system, inhibiting the activation of 5-HT receptors on gastrointestinal neurons, and reducing intestinal secretion, Peristalsis and afferent pain signals. For the treatment of women with diarrhea as the main symptom of irritable bowel syndrome, but also for the treatment of abdominal pain, urgency, frequent stools and other symptoms. |
Risk Codes | R25 - Toxic if swallowed R36 - Irritating to the eyes R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 2811 6.1 / PGIII |
WGK Germany | 3 |
HS Code | 2933790002 |